<p>Medicamente: anti-cancer , anti-diabet, anti-infectioase, anti-inflammatorii, anti-lipemianti, cardiovasculare, estrogeni, gastrointestinale, immunosupresive post-transplant, pentru tractul urinar sau sistemul nervos, antalgice precum diazepamul sau opiodie. Peste 85 de medicamente sunt influentate printr-o interactiune cu grepfruitul.</p>
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<p>methylprednisolone -oral, amlodipine, felodipine, losartan, manidipine, nicardipine, felodipine, losartan, manidipine, nicardipine, nimodipine, nisoldipine, nitrendipine, propafenone, quinidine, rivaroxaban, sibutramine,sildenafil, tadalafil, vardenafil, diazepam, fluvoxamine, methadone, midazolam –</p>
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<p>quazepam,sertraline,triazolam,estradiol,ethinylestradiol, darifenacin, fesoterodine, solifenacin, silodosin, silodosin, etravirine, artemether, etravirine, aprepitant, carbamazepine<br />
In combinatie cu anumite medicamente, practic, grapefruitul poate induce supradozaj medicamentos, lucru ce poate duce la, spre exemplu:</p><div class="amp-ad-wrapper amp_ad_1 ampforwp-incontent-custom-banner ampforwp-incontent-ad3"><amp-ad width="336" height="280" type="sulvo" data-ad="andreilaslau.ro_amp_display_336x280" class="demand-supply"></amp-ad></div><div class="amp-ad-wrapper amp_ad_1 ampforwp-incontent-custom-banner ampforwp-incontent-ad1"><amp-ad width="336" height="280" type="sulvo" data-ad="andreilaslau.ro_amp_display_336x280" class="demand-supply"></amp-ad></div><div class="b03d97280e765d707d336f444dd9d428" data-index="10" style="float: none; margin:0px 0 0px 0; text-align:center;">
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<p>insuficienta renala, insuficienta respiratorie acuta, sangerari in tractul digestiv, aritmii cu potential fatal, hipoglicemie, hiperglicemie, hipotensiune, bradicardie, hipopotasemie, halucinatii, sedare, nefrotoxicitate, sangerari renale samd.<br />
Cantitatea periculoasa este foarte mica &#8211; e de ajuns un pahar de suc pentru efecte potential fatale. Sau cateva feliute. De aceea, trebuie sa fiti siguri ca medicamentele pe care le luati nu interactioneaza cu grapefruitul.<br />
Mecanismul de actiune este explicat mai jos &#8211; practic, grapefruitul inhiba CYP34A de la nivelul enterocitului sau hepatocitului, lucru ce duce la supradozare de medicament, chiar in conditiile in care s-a luat doza corecta. Mecanismul mai amplu, in video<br />
Chiar şi aşa, doi americani, Stewart şi Lynda Resnick vor să transforme trăsăturile „negative” ale fructului într-o afacere profitabilă, aşa cum au făcut şi cu fructe precum rodia sau mandarina, prin compania lor, Wonderful Company.</p>
<p>Pentru a realiza acest lucru, compania a cumpărat terenuri întinse de plantaţii, locaţii pentru ambalare şi o instalaţie de prelucrare. În speranţa că va reuşi să reinventeze felul în care este perceput grapefruitul şi să vândă mari cantităţi consumatorilor, Wonderful Company a introdus noi metode de plantare şi tăiere a grapefruitului.<br />
surse: <a href="http://www.cmaj.ca/content/suppl/2012/11/26/cmaj.120951.DC1/grape-bailey-1-at.pdf">cmj.ca</a> ,<br />
<a href="http://bigthink.com/neurobonkers/the-forbidden-fruit-how-grapefruit-could-kill-you">bigthink.com</a> ,<br />
<a href="https://ro.wikipedia.org/wiki/Grepfrut">ro.wikipedia.org</a>,<br />
<a href="https://en.wikipedia.org/wiki/Grapefruit">en.wikipedia.org</a></p>
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